Double Floxed Fbxw7/FoxM1
- Name Abdolrahman Shams-Nateri
- Institute University of Nottingham
Tool name: Double Floxed Fbxw7/FoxM1
Alternate names: F-box/WD repeatâ€“containing protein 7, CDC4, Sel1, Ago, Fbw7, SCF, Skp1/Cullin/F-box protein, E3 ubiquitin ligase complex,FBW6, FBX3, FBXO3, FBXW6, SEL-1, hAgo, hCdc4, FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1
Tool type: Experimental models
Tool sub-type: Mouse
Genetic background and cross history: This model was created by interbreeding the floxed-Fbxw7 mouse with a floxed-FoxM1 mouse (for floxed-FoxM1 mouse see references).
Description: FoxM1 is plays a key role in the cell cycle as endogenous expression peaks at the S and G2/M phases, crucial for mitotic division. Recent studies have shown that FOXM1 regulates expression of a large array of G2/M-specific genes which play a crucial role in maintenance of genomic stability and chromosomal segregation. There are 3 known isoforms of FoxM1, A, B & C and it is a known human proto-oncogene, involved in basal cell carcinoma.
Fbxw7 is a member of the F-box protein family, characterised by a motif of approximately 40 amino acids called the F-box. These proteins constitute one of the four subunits of ubiquitin protein ligase complex called SKP1-cullin-F-box and function in phosphorylation-dependent ubiquitination. Fbxw7 specifically protein contains 7 tandem solenoid protein domains also know as WD40 repeats. Fbwx7 binds directly to cyclin E and probably targets it for ubiquitin-mediated degradation.
Research area: Cancer ; Drug Discovery & Development ; Metabolism
- For Research Use Only
- • Yoshida et al. 2007. Gastroenterology. 132(4):1420-31. PMID: 17408638.
- • The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.
- • Wang et al. 2002. Proc Natl Acad Sci U S A. 99(26):16881-6. PMID: 12482952.
- • The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.