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Contributor Information

  • Name Bart Vanhaesebroeck
  • Institute Ludwig Institute for Cancer Research ; The University of Edinburgh

Tool Details

  • Tool name: p110beta PI3K-floxed
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Model: Conditional KO
  • Conditional: Yes
  • Cell signalling pathway: PI3K/AKT signalling
  • Genetic background and cross history: Exons 21 and 22 of the PIK3CA/p110b PI3K gene are flanked by LoxP sites - backcrossed onto C57B6/J background.
  • Phenotype: Homozygous and heterozygous mice are phenotypically normal.
  • Research area: Cancer
  • Production details: Exons 21 and 22 of the PIK3CA/p110b PI3K gene are flanked by LoxP sites - backcrossed onto C57B6/J background.
  • Additional notes: Homozygous and heterozygous mice are phenotypically normal.

  • For Research Use Only

Target Details

  • Target: PIK3CB

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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  • Available on request

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References

  • •  Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
  • •  Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.