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Contributor Information

  • Name Robert Zimmermann ; Franz Radner
  • Institute University of Graz

Tool Details

  • Tool name: MAGL-Flox mouse
  • Alternate names: MGL, Mgll, Magl
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: Targeted, conditional ready
  • Genetic background and cross history: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are regularly backcrossed to C57BL/6J to avoid generation of subpopulations.
  • Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
  • Zygosity: Homozygous
  • Strain: C57BL/6J
  • Description: Useful model for the generation of tissue/cell specific MAGL-deficient mice. Animals might be useful for studies, e.g. on energy metabolism or endocannabinoid signalling.
  • Research area: Metabolism; Cell Signaling & Signal Transduction
  • Production details: A floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette leaving Mgll exon 3 and 4 floxed. Further details are available upon request.
  • Breeding information: Good breeder. homozygous mice may be bred together to maintain a live colony.

  • For Research Use Only

Target Details

  • Target: Monoglyceride lipase; monoacyl glycerol lipase

Application Details



  • Available on request


  •   21454566
  •   26565024