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Contributor Information

  • Name Saverio Tardito
  • Institute Cancer Research UK Glasgow: The Beatson Institute
  • Primary citation Vande Voorde et al. 2019. Sci Adv. 5(1):eaau7314. PMID: 30613774

Tool Details

  • Tool name: PlasmaxTM cell culture medium
  • Tool type: Media
  • Tool sub-type: Cell culture media
  • Purpose: Physiologically relevant cell culture medium which mimics the metabolic and physiological profile of human plasma
  • Application: Cell culture; Cell growth and viability
  • Description: PlasmaxTM is a new physiologically relevant cell culture medium which mimics the metabolic and physiological profile of human plasma. It is designed to improve the metabolic fidelity and biological relevance of in vitro cancer models by recapitulating the natural in vivo metabolic environment in an in vitro setting. Researchers have found that conventional growth-focused media with non-physiological concentrations of nutrients and metabolites can skew the metabolic profile of cancer cells. PlasmaxTM is optimised from over 80 components, including amino acids and derivatives, inorganic salts, trace elements, and vitamins, of which over 50 are at levels found in human plasma. PlasmaxTM is also the only ready-to-use cell culture media containing growth-enhancing trace elements including vanadium, zinc, manganese, copper and selenium. PlasmaxTM can be used by cancer researchers interested in cancer cell biology. It has been validated for growth performance and metabolic fidelity in several widely-used triple-negative breast cancer cell lines.
  • Formulation: Complete and ready-to-use cell culture medium. For the media formulation, please, see Documentation
  • Research area: Cancer, Cell biology

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Liquid
  • Volume: 500 ml
  • Storage conditions: Stable for 12 months at 4°C
  • Mycoplasma free: Yes

Documentation

    Download Icon Plasmax MSDS
    Download Icon Plasmax application note
    Download Icon Plasmax brochure
    Download Icon Plasmax formulation
  • Available on request

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References

  • •  Bagshawet al. Mitochondrial Intoxication. 2023, 723-744
  • •  Gassl et al. Cancers (Basel) 2022 Nov 16,14(22):5617. PMID: 36428711
  • •  Wang et al. Biomolecules 2022 Oct 27,12(11):1575. PMID: 36358924
  • •  Villar et al. 2022. Nat Chem Biol. PMID: 36280791
  • •  Gardner et al. 2022. Am J Physiol Cell Physiol 323(3):C823-C834. PMID: 35876286
  • •  Golikov et al. 2022. Mol Biol (Mosk) 56(5):687-696. PMID: 36165010
  • •  Taurino et al. 2022. Mol Metab. 101532 PMID: 35752287
  • •  Wang et al. 2022. Biomolecules. 12(6):743. PMID: 35740868
  • •  Bagshaw et al. 2021. Biomaterials and Biosystems.4 (100027): 2666-5344
  • •  Golikov et al. 2022. Antioxidants 2022, 11, 97.
  • •  Golikov et al. Antioxidants 2022, 11(1), 97
  • •  Kalimuthu et al. 2021. J Cell Biochem. :. PMID: 34935169.
  • •  Hennequart et al. 2021. Nature Communications. 12: 6176.
  • •  Chiu et al. 2021. American Society of Hematology. Blood Advances.
  • •  Cox et al. 2020. Journal of Data and Information Science. 5(3): 161-177
  • •  Moradi et al. 2021. Biomolecules. 11(8): 1177
  • •  Plasmax Application Note
  • •  Barekatain et al. 2021. Nature. 12: 4228.
  • •  Moradi et al. 2021. American Journal of Physiology. Cell Physiology. 321 (1): C72-C81.
  • •  Khadka et al. 2021. Cancer & Metabolism. 9:27
  • •  Abbas et al. 2021. Comp Biochem Physiol B Biochem Mol Biol. 254:110570. PMID: 33516822.
  • •  PlasmaxTM: Product Brochure
  • •  Ackermann et al. 2019. Trends Cancer. 5(6):329-332. PMID: 31208694.
  • •  Cell culture shock – a scientist’s hunt for the perfect cocktail
  • •  Vande Voorde et al. 2019. Sci Adv. 5(1):eaau7314. PMID: 30613774.