Organoids are unique self-organising 3D microscopic structures derived from cells that represent a physiologically relevant in vitro model systems as they preserve the genomic, physiological characteristics and multicellularity of the equivalent in vivo tissue
Preserve parental tissue genetic profile and morphology: various characterisation tests confirm F-PDOs retain parental tissue genetic profile and morphology
Amenable to extended culture duration: genetically and phenotypically stable for 6 -12 months in culture and after cryopreservation
Suspension culture: no extracellular matrix required
In vivo tumorigenesis: suitable for PDX mouse development - gene expression profiles of the xenografts are similar to those of their source F-PDOs and tissues
Suitable for various assays: F-PDOs can be used to establish high-throughput assays to evaluate anticancer agents and antibodies
Well-characterized with annotation data: the organoids have been characterised using comprehensive gene expression, whole-exome sequencing and morphological analyses
Disease modelling
Anticancer agents discovery and development
Immuno-oncology assays
Compounds’ safety and toxicity testing
|
CancerTools.org is the research tools arm of Cancer Research UK, a registered charity in England and Wales (1089464), Scotland (SCO41666), the Isle of Man (1103) and Jersey (247).