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Contributor Information

  • Institute Clonegene LLC

Tool Details

  • Tool name: Paraneoplastic Hu Antigen, Recombinant Protein [5]
  • Tool type: Proteins
  • Source: E.coli
  • Expression system: Recombinant
  • Description: HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
  • Research area: Cancer ; Developmental Biology ; Gene Expression ; Neurobiology
  • Tag: MBP fusion protein

  • For Research Use Only

Target Details

  • Target: HuD

Application Details

Handling

  • Storage conditions: Store at 4°C; long term storage at -20°C
  • Shipping conditions: Dry Ice

Documentation

  • Available on request