Paraneoplastic Hu Antigen, Recombinant Protein 
Tool name: Paraneoplastic Hu Antigen, Recombinant Protein 
Tool type: Proteins
Expression system: Recombinant
Description: HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein.
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
Research area: Cancer ; Developmental Biology ; Gene Expression ; Neurobiology
Tag: MBP fusion protein
- For Research Use Only