CHEC-7 immunomodulatory Peptide
- Name Timothy Cunningham
- Institute Drexel University
Tool name: CHEC-7 immunomodulatory Peptide
Alternate names: Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP)
Tool type: Proteins
Description: The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor. The neuroprotective/anti-inflammatory cyclic heptapeptide, CHEC-7, stimulates HSP70's disaggregase activity and is used in the study of protein aggregate disease, including age-related failures of protein repair like Alzheimerâs Disease. The peptide also showed promising results in treating Autoimmune Myeloencephalitis tested in a rat model.
Research area: Immunology ; Neurobiology
- For Research Use Only
- • Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.
- • Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
- • Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis