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Contributor Information

  • Name Timothy Cunningham
  • Institute Drexel University

Tool Details

  • Tool name: CHEC-7 immunomodulatory Peptide
  • Alternate names: Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP)
  • Tool type: Proteins
  • Sequence: CHEASQC
  • Description: The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor. The neuroprotective/anti-inflammatory cyclic heptapeptide, CHEC-7, stimulates HSP70's disaggregase activity and is used in the study of protein aggregate disease, including age-related failures of protein repair like Alzheimer’s Disease. The peptide also showed promising results in treating Autoimmune Myeloencephalitis tested in a rat model.
  • Research area: Immunology; Neurobiology

  • For Research Use Only

Target Details

Application Details

Handling

  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.
  • •  Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
  • •  Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis