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Contributor Information

  • Name Prakash Lingasamy ; Tambet Teesalu
  • Institute University of Tartu

Tool Details

  • Tool name: PL5 Peptide
  • Alternate names: PL5, Bi-specific tenascin-C and fibronectin targeted peptide
  • Tool type: Proteins
  • Tool sub-type: Synthetic Peptide
  • Sequence: PPRRGLIKLKTSSNTKENSVVASLRP
  • Expression system: Synthetic
  • Function: Marker
  • Description: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are not present in the extracellular matrix of adult tissues but they are up-regulated in tumours and malignant tissues. Both have been used as targets for antibody-based therapies. This bi-specific peptide has enhanced affinity to bind to these receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.
  • Research area: Cancer ; Extracellular Matrix
  • Purpose: Marker

  • For Research Use Only

Target Details

  • Target: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)

Application Details

Handling

  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.