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Contributor Information

  • Name Tambet Teesalu ; Prakash Lingasamy
  • Institute University of Tartu

Tool Details

  • Tool name: PL1 peptide
  • Alternate names: PL1, FN-EDB and TNC-C binding protein
  • Tool type: Proteins
  • Tool sub-type: Synthetic Peptide
  • Sequence: PPRRGLIKLKTS
  • Expression system: Synthetic
  • Function: Marker
  • Description: PL1 peptide is a short binding peptide which interacts with oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C) which are both extracellular matrix proteins present in a tumour microenvironment. The targets of PL1 are nearly absent in normal adult tissues making them indicative of solid tumour tissues. It has been shown that this dual-targeted peptide can be used for robust and specific delivery of imaging agents and therapeutic payloads to solid tumours.
  • Research area: Cancer ; Extracellular Matrix
  • Purpose: Marker

  • For Research Use Only

Target Details

  • Target: Oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C). Relevant disease: Cancer

Application Details

Handling

  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery