PROTEINS
Contributor Information
- Name Tambet Teesalu ; Prakash Lingasamy
- Institute University of Tartu
Tool Details
- Tool name: PL1 peptide
- Alternate names: PL1, FN-EDB and TNC-C binding protein
- Tool type: Proteins
- Tool sub-type: Synthetic Peptide
- Sequence: PPRRGLIKLKTS
- Cellular/ tissue localisation: Extracellular matrix
- Expression system: Synthetic
- Function: Marker
- Description: PL1 peptide is a short binding peptide which interacts with oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C) which are both extracellular matrix proteins present in a tumour microenvironment. The targets of PL1 are nearly absent in normal adult tissues making them indicative of solid tumour tissues. It has been shown that this dual-targeted peptide can be used for robust and specific delivery of imaging agents and therapeutic payloads to solid tumours.
- Research area: Cancer; Cell biology
- Purpose: Marker
- For Research Use Only
Target Details
- Target: Oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C). Relevant disease: Cancer
Application Details
Handling
- Shipping conditions: Dry Ice
Documentation
Related Tools
References
- • Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery
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