PROTEINS
Contributor Information
- Name Jean-Philippe Girard
- Institute University of Toulouse
Tool Details
- Tool name: "Super-active" Interleukin-33 (IL-33) fragment Peptide
- Alternate names: Interleukin-33, IL-33, C9orf26, IL1F11, NFHEV
- Tool type: Proteins
- Tool sub-type: Cytokine
- Source: Plasmid
- Function: Recombinant Protein; Agonist
- Description: Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines. IL-33 is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. Extracellular IL-33 activates a growing number of target cells, including group 2 innate lymphoid cells, mast cells and regulatory T cells. It can be used in life science research to induce inflammation in vivo and in vitro. IL-33 has also been shown to be effective in reversing Alzheimer-like symptoms in APP/PS1 mice, by reversing the buildup and preventing the new formation of amyloid plaques.
- Research area: Immunology
- Purpose: Recombinant Protein; Agonist
- Additional notes: This fragment of IL-33 has been shown to be more strongly activate inflammatory responses in cells than the full-length protein, making it a good tool for inflammatory research. Patent FR2972006A1: https://worldwide.espacenet.com/patent/search/family/044533285/publication/FR2972006A1?q=FR2972006A1
- For Research Use Only
Target Details
- Target: Interleukin-33
Application Details
- Application notes: This fragment of IL-33 has been shown to be more strongly activate inflammatory responses in cells than the full-length protein, making it a good tool for inflammatory research. Patent FR2972006A1: https://worldwide.espacenet.com/patent/search/family/044533285/publication/FR2972006A1?q=FR2972006A1
Handling
- Shipping conditions: Dry Ice
Documentation
- Available on request
Related Tools
References
- • Lefrançais et al. 2012. Proc Natl Acad Sci U S A. 109(5):1673-8. PMID: 22307629.
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