- Name Andrzej Gamian ; Edmund Ziomek ; Danuta Witkowska ; Anna Ewelina JarzÄ
- Institute Polski O?rodek Rozwoju Technologii (PORT) Polish Center for Technology Development
Tool name: RYDERY Peptide
Alternate names: Shigella flexneri 3a OMP
Tool type: Proteins
Cellular/ tissue localisation: Umbilical blood
Description: The genus Shigella belongs to Gram-negative opportunistic human pathogens and is responsible for colonic infections. Symptoms of infection include lower abdominal pain, fever and bloody diarrhoea which may cause a life threatening dehydration. Bacterial diarrhoea is in third place world wide in terms of causes of juvenile mortality below the age of five years. Infant and child mortality due to bacterial infections are generally caused by low standards of sanitation pervasive in developing nations. Nevertheless, infections by pathogenic intestinal bacteria, including Shigella, also occur in developed nations. Here, a bigger problem consists of strains resistant to antibiotics. For this reason, healthcare authorities both in developing and developed nations are pushing for prevention, including vaccination. Thus far, no one has managed to produce a vaccine against opportunistic bacterial pathogens of the gastrointestinal tract.
Research area: Drug Discovery & Development; Immunology
- For Research Use Only
- • JarzÄ
b et al. 2013. PLoS One. 8(8):e70539. PMID: 23940590.