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Contributor Information

  • Name Geoffrey Margison
  • Institute Cancer Research UK, Manchester Institute

Tool Details

  • Tool name: MGMT inhibitor Lomeguatrib Small Molecule (Tool Compound)
  • Alternate names: PaTrin 2
  • Molecular formula: C10H8BrN5OS
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The MGMT inhibitor Lomeguatrib is a potent inhibitor of O6-alklguanine-DNA-alkyltransferase. It shows antitumoral activity in vivo in combination with the compound Temozolomide.
  • Research area: Cell Signaling & Signal Transduction

  • For Research Use Only

Target Details

  • Target: DNA repair protein MGMT and related mammalian proteins

Application Details

Handling

  • Purity: 326.17 g/mol
  • Solubility:
  • Storage conditions: Ambient
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Barvaux et al. 2004. Mol Cancer Ther. 3: 1215-20 (PMID: 15426188) Clemons et al. 2005. Br J Cancer. 93: 1152-6 (PMID: 16278661) Ranson et al. 2006. Clin Cancer Res. 12: 1577-84 (PMID: 16533784) Khan et al. 2008 Br J Cancer. 98: 1614-8 (PMID: 18475294) Watson et al. 2010. Clin Cancer Res. 16: 743-9 (20068091)