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Contributor Information

  • Name Mark Charles
  • Institute Cancer Research Technology

Tool Details

  • Tool name: Protein Kinase D inhibitor CRT0066101 Small Molecule (Tool Compound)
  • Molecular formula: C18H23CIN6
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The Protein Kinase D inhibitor CRT0066101 is a potent antitumoral agent in vitro and in vivo. Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity. Studies on PKD thus far indicate a striking diversity of both its signal generation and distribution and its potential for complex regulatory interactions with multiple downstream pathways, often regulating the subcellular localization of its targets.
  • Research area: Cancer ; Cell Signaling & Signal Transduction ; DNA Damage and Repair

  • For Research Use Only

Target Details

  • Target: Protein Kinase D (PKD)

Application Details

Handling

  • Purity: 374.86776 g/mol
  • Solubility:
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Harikumar et al. 2010. Mol Cancer Ther. 9:1136-1146.PMID: 20442301 Ochi et al. 2011. Journal of Cellular Physiology. 226: 1074-1081. PMID: 20857418 Yuang et al. 2012. Frontiers in Physiology. 3:60. PMID: 22470346 Yang et al. 2013. PNAS (vol 10:6-2312-17). PMID: 23345428 Berhnart et al. 2013. Experimental Cell Research (vol319)-2037-2048. PMID: 23562655 Wei et al. 2014. Molecular Cancer Therapeutics. PMID: 24634417 Ryvkin et al. 2015. J Biol Chem. 290(17):11199-208. PMID: 25802335.