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Contributor Information

  • Name Mark Charles
  • Institute Cancer Research Technology

Tool Details

  • Tool name: LIMK inhibitor CRT0105950 Small Molecule (Tool Compound)
  • Molecular formula: C20H18F3N3O2S
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The LIMK inhibitor CRT0105950 is a novel, selective, potent LIMK inhibitor, which inhibits p-cofilin and inhibits invasion in a Matrigel inverse invasion assay. LIMK1 has been reported to play a key role in tumour cell invasion, and the level of LIMK1 is increased in breast and prostate cancer cell lines in comparison with less invasive cell lines. The LIM kinases (LIMK1 and LIMK2) phosphorylate and inactivate cofilin which allows them to act as regulators of actin cytoskeletal dynamics and microtubule organisation.
  • Research area: Cell Signaling & Signal Transduction ; Metabolism ; Neurobiology

  • For Research Use Only

Target Details

  • Target: LIMK1 and LIMK2

Application Details

Handling

  • Purity: 383.89 g/mol
  • Solubility:
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Charles et al. 2015. J Med Chem. :. PMID: 26356364