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Contributor Information

  • Name Malcolm F G Stevens
  • Institute University of Nottingham

Tool Details

  • Tool name: Antitumoral Quinol1h Small Molecule (Tool Compound)
  • Molecular formula: C20H14FNO4S
  • Tool type: Small molecules
  • Description: A new class of molecule (4-hydroxy-4-hetarylcyclohexa-2,5-dien-1-ones) bearing a new pharmacophore (quinols') has been identified with potent activity against renal, colon and breast cell lines in the NCI 60-cell panel.
  • Research area: Cell Cycle ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target: Thioredoxin reductase

Application Details

Handling

  • Purity: 383.4 g/mol
  • Solubility: DMSO to 100 mM
  • Storage conditions: -20°C (desiccating conditions)
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Chew et al. 2008. FASEB J. 22(6):2072-83. PMID: 18180330.
  •   Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity.
  •   Berry et al. 2005. J Med Chem. 48(2):639-44. PMID: 15658878.
  •   Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
  •   Wells et al. 2003. J Med Chem. 46(4):532-41. PMID: 12570375.
  •   4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.