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Contributor Information

  • Name Laurent Rigoreau
  • Institute Cancer Research Technology

Tool Details

  • Tool name: AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)
  • Molecular formula: C15H20CIN3O2
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Molecular weight of the target: 309.79
  • Description: CRT0093964 is a highly potent and selective inhibitor of the Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3).
  • Research area: Cell Signaling & Signal Transduction; Metabolism; Neurobiology
  • Selectivity: Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any COX (cyclooxygenase) inhibition at 10 ÂľM in whole blood assay.
  • IUPAC: 4-(4-Chloro-phenyl)-piperazin-1-yl]-morpholin-4-yl-methanone
  • IC50: IC50 = 88 nM
  • Additional notes: Referred to as A9 in Khanim et al., 2014.

  • For Research Use Only

Target Details

  • Target molecular weight: 309.79
  • Primary target: Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3)

Application Details

Handling

  • Purity: 309.79 g/mol
  • Shipping conditions: Dry Ice

Documentation

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  • Available on request

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References

  • •  Khanim et al. 2014. Br J Cancer. 110(6):1506-16. PMID: 24569460.