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Contributor Information

  • Name Bernard Golding ; Laurent Rigoreau
  • Institute Newcastle University

Tool Details

  • Tool name: DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)
  • Alternate names: DNA-dependent protein kinase (DNA-PK) inhibitor NU7441
  • Molecular formula: C25H19NO3S
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: NU7441 is a highly potent and selective DNA-PK inhibitor.
  • Research area: Cell Signaling & Signal Transduction ; DNA Damage and Repair ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target: DNA-dependent protein kinase (DNA-PK)

Application Details

Handling

  • Purity: 413.49 g/mol
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Zhao et al. 2006. Cancer Res. 66(10):5354-62. PMID: 16707462.
  •   Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
  •   Leahy et al. 2004. Bioorg Med Chem Lett. 14(24):6083-7. PMID: 15546735.
  •   Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.