HDAC2/3 inhibitor MI-192 Small Molecule (Tool Compound)
- Name Ron Grigg
- Institute University of Leeds
Tool name: HDAC2/3 inhibitor MI-192 Small Molecule (Tool Compound)
Molecular formula: C24H21N3O2.HCl
Tool type: Small molecules
Tool sub-type: Inhibitor
Description: MI-192 is a novel benzamide-based compound with marked selectivity for the class I enzymes, HDAC2 (histone-deacetylase 2) and HDAC3 (histone-deacetylase 3). MI-192 is also a histone-deacetylase (HDAC)-3 selective inhibitor.
MI-192 might have potential in the treatment of rheumatoid arthritis, and HDAC-selective inhibition may improve the therapeutic margin of safety.
Studies in various cancer cell lines have also revealed that MI-192 might be a potential therapeutic agent for use in leukaemia.
Research area: Apoptosis and Programmed Cell Death ; Cancer ; Plant Science
- For Research Use Only
- • WO2013005049