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Contributor Information

  • Name Julian Blagg
  • Institute The Institute of Cancer Research

Tool Details

  • Tool name: Mps1 inhibitor CCT251455 Small Molecule (Tool Compound)
  • Molecular formula: C26H26ClN7O2
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The Mps1 inhibitor CCT251455 is a potent and selective chemical tool stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding. MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers.
  • Research area: Cancer

  • For Research Use Only

Target Details

  • Target: Monopolar spindle 1 (Mps1, also known as TTK)

Application Details

Handling

  • Purity: 503.99 g/mol
  • Solubility:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   J. Med. Chem. 2013, 56, 10045-10065. PMID: 24256217