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Contributor Information

  • Name Roger Griffin
  • Institute Newcastle University

Tool Details

  • Tool name: CDK2 inhibitor NU6301 Small Molecule (Tool Compound)
  • Molecular formula: C18H21N6O4S1(CH3)- K+
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The CDK2 inhibitor NU6301 is a water soluble prodrug of NU6102, a potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). CDK2 is a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. CDK2 is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. CDK2 associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B).
  • Research area: Cancer

  • For Research Use Only

Target Details

  • Target: Cyclin dependent kinase 2 (CDK2)

Application Details

Handling

  • Purity:
  • Solubility:
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Thomas, H et al
  •   European Journal of Cancer, Volume 47, Issue 13, September 2011, Pages 2052–2059