Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)
- Name Michael Coogan
- Institute Lancaster University
Tool name: Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)
Molecular formula: (ReO3N3CO)3ReAgO
Tool type: Small molecules
Tool sub-type: Luminophore
Molecular weight of the target: 1735
Description: Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
Research area: Cancer; Cell Cycle
Additional notes: Ag-1:
Îť max excitation = 371 nm (broad peak extends into the visible and can be excited at 405 nm in microscopy)
Îť max emission = 571;
lifetime Ď = 21 ns.
Ag-1 does not release Ag+ except under forcing conditions, unlike physiological conditions.
- For Research Use Only
- • Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.