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Contributor Information

  • Name Michael Coogan
  • Institute Lancaster University

Tool Details

  • Tool name: Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)
  • Molecular formula: (ReO3N3CO)3ReAgO
  • Tool type: Small molecules
  • Tool sub-type: Luminophore
  • Molecular weight of the target: 1735
  • Description: Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
  • Research area: Cancer; Cell Cycle
  • Additional notes: Ag-1: Îť max excitation = 371 nm (broad peak extends into the visible and can be excited at 405 nm in microscopy) Îť max emission = 571; lifetime τ = 21 ns. Ag-1 does not release Ag+ except under forcing conditions, unlike physiological conditions.

  • For Research Use Only

Target Details

  • Target molecular weight: 1735

Application Details

Handling

  • Purity: 1735 g/mol
  • Solubility: DMSO
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.