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Contributor Information

  • Name Michael Coogan
  • Institute Lancaster University

Tool Details

  • Tool name: Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)
  • Molecular formula: (ReO3N3CO)3ReAgO
  • Tool type: Small molecules
  • Description: Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
  • Research area: Cancer ; Cell Cycle

  • For Research Use Only

Target Details

Application Details

Handling

  • Purity: 1735 g/mol
  • Solubility: DMSO
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.