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Contributor Information

  • Name Dr Ian Waddell
  • Institute Cancer Research UK Manchester Institute

Tool Details

  • Tool name: Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Collaborative Toolkit)
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Cancer type: Head and neck cancer; Digestive / Gastrointestinal cancer
  • Molecular weight of the target: 1.0 ÂľM
  • Description: A selective inhibitor of Glucose-6-phosphate dehydrogenase (G6PD) which demonstrates anti-cancer activity. G6PD is a critical metabolic enzyme involved in the oxidative phase of the pentose phosphate pathway. Chinese hamster ovary cells that are devoid of G6PD display increased sensitivity to radiation and human fibroblasts deficient in G6PD display increased ROS and radiation sensitivity. Clinically, evidence from studies in larynx and gastric cancer suggests that tumours show increased G6PD activity, and this correlates to a poor clinical outcome. Synonyms for Glucose-6-phosphate Dehydrogenase: G6PD; G6PD1; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase; glucose-6-phosphate dehydrogenase, glucose 6 phosphate dehydrogenase
  • Selectivity: Inhibitory activity against related targets as % inhibition at given concentration: 6PGDH: 4.7% at 200 ÂľM IDH: 0.9% at 200 ÂľM RET: 4.8% at 100 ÂľM LSD1: 6.3% at 40 ÂľM
  • IC50: 1.0 ÂľM

  • For Research Use Only

Target Details

  • Target molecular weight: 1.0 ÂľM
  • Primary target: Glucose-6-phosphate dehydrogenase (G6PD)

Application Details

  • Application notes: Cell permeability: Caco2 Permeability: 31.6 x 10-6 cm/s (efflux ratio 0.54)


  • Purity: 360.5 kDa
  • Solubility: 30-100ÂľM in PBS



  •   Hamilton et al. 2012. J Med Chem. 55(9):4431-45. PMID: 22506561.
  •   Hitchin et al. 2012. Tetrahedron Letters. 53:2868-72