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Contributor Information

  • Name Simak Ali
  • Institute Imperial College London

Tool Details

  • Tool name: CDK inhibitor BS-194 Small Molecule (Tool Compound)
  • Molecular formula: C20H27N5O3
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Molecular weight of the target: 385.5
  • Description: BS-194 is a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9.
  • Research area: Cancer; Epigenetics & Nuclear Signalling; Gene Expression
  • Selectivity: CDK1, CDK2, CDK7, and CDK9
  • IUPAC: (2S,3S)-3-(7-(benzylamino)-3- isopropylpyrazolo[1,5-a]pyrimidin-5- ylamino)butane-1,2,4-triol
  • IC50: CDK2, CDK1, CDK5, CDK7, and CDK9 (IC50=3, 30, 30, 250, and 90 nmol/L, respectively)

  • For Research Use Only

Target Details

  • Target molecular weight: 385.5

Application Details

Handling

  • Purity: 385.5 g/mol
  • Storage conditions: Ambient
  • Shipping conditions: Dry Ice

Documentation

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  • Available on request

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References

  • •  J. Med. Chem. 2010, 53, 8508–8522