PI4K beta Inhibitor Small Molecule (Tool Compound)
- Name Martin Swarbrick
- Institute Cancer Research Technology AstraZeneca Metabolism Alliance Team
Tool name: PI4K beta Inhibitor Small Molecule (Tool Compound)
Molecular formula: C23H25N5O4S2
Tool type: Small molecules
Tool sub-type: Inhibitor
Description: Potent and selective small molecule inhibitor of PI4K?, an isoform mainly associated with the Golgi complex where it functions in the generation of Golgi-derived carriers. In addition to the Golgi apparatus, PI4K? has also been visualised on lysosomes where it functions to maintain lysosomal membrane integrity. In a cellular environment, inhibition of PI4K? does not lead to a reduction in phosphatidylionositol-4-phosphate and phosphatidylionositol-4,5-biphosphate concentration
Research area: Cancer
- For Research Use Only
- • Raubo et al. 2015. Bioorg Med Chem Lett. 25(16):3189-93. PMID: 26087940.
Waring et al. 2014. Chem Commun (Camb). 50(40):5388-90. PMID: 24366037.