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Contributor Information

  • Name Martin Swarbrick
  • Institute Cancer Research Technology AstraZeneca Metabolism Alliance Team

Tool Details

  • Tool name: PI4K beta Inhibitor Small Molecule (Tool Compound)
  • Molecular formula: C23H25N5O4S2
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Molecular weight of the target: 499.13
  • Description: Potent and selective small molecule inhibitor of PI4K?, an isoform mainly associated with the Golgi complex where it functions in the generation of Golgi-derived carriers. In addition to the Golgi apparatus, PI4K? has also been visualised on lysosomes where it functions to maintain lysosomal membrane integrity. In a cellular environment, inhibition of PI4K? does not lead to a reduction in phosphatidylionositol-4-phosphate and phosphatidylionositol-4,5-biphosphate concentration
  • Research area: Cancer
  • Selectivity: 5.1 (PI4KÎą); 4.7 (PI3KÎą); <4.0 (PIP5KÉŁ); no activity against any kinase in the Millipore kinase panel (259 kinases; tested at 1ÂľM)
  • IC50: 7.8 (PI4Kβ)
  • Additional notes: Compound 3 (PMID: 24366037). AstraZeneca Alliance.

  • For Research Use Only

Target Details

  • Target molecular weight: 499.13

Application Details

Handling

  • Purity: 499.13 g/mol
  • Solubility: 5 ľM
  • Shipping conditions: Dry Ice

Documentation

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  • Available on request

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References

  • •  Raubo et al. 2015. Bioorg Med Chem Lett. 25(16):3189-93. PMID: 26087940. Waring et al. 2014. Chem Commun (Camb). 50(40):5388-90. PMID: 24366037.