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Contributor Information

  • Name Martin Swarbrick
  • Institute Cancer Research Technology AstraZeneca Metabolism Alliance Team

Tool Details

  • Tool name: PI4K beta Inhibitor Small Molecule (Tool Compound)
  • Molecular formula: C23H25N5O4S2
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: Potent and selective small molecule inhibitor of PI4K?, an isoform mainly associated with the Golgi complex where it functions in the generation of Golgi-derived carriers. In addition to the Golgi apparatus, PI4K? has also been visualised on lysosomes where it functions to maintain lysosomal membrane integrity. In a cellular environment, inhibition of PI4K? does not lead to a reduction in phosphatidylionositol-4-phosphate and phosphatidylionositol-4,5-biphosphate concentration
  • Research area: Cancer

  • For Research Use Only

Target Details

Application Details

Handling

  • Purity: 499.13 g/mol
  • Solubility: 5 ľM
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Raubo et al. 2015. Bioorg Med Chem Lett. 25(16):3189-93. PMID: 26087940. Waring et al. 2014. Chem Commun (Camb). 50(40):5388-90. PMID: 24366037.