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Contributor Information

  • Name Christoph J. Fahrni
  • Institute Georgia Institute Of Technology

Tool Details

  • Tool name: Fluorescent probe for Copper
  • Tool type: Small molecules
  • Tool sub-type: Fluorescent Probe
  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
  • Description: Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. Here, Dr. Farhrni has designed a water-solube fluorescence probe for the detection of aqueous Cu(I). This probe has a high selectivity (57-fold) for Cu(I) compared to other cations such as Cu(II), Hg(II), and Cd(II).
  • Research area: Drug Discovery & Development; Other

  • For Research Use Only

Target Details

Application Details

  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands

Handling

  • Solubility: water

Documentation

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References

  • •  Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.
  • •  High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.