[Src/Abl1] Inhibitor AZD0424 Small Molecule Tool Compound
Tool name: [Src/Abl1] Inhibitor AZD0424 Small Molecule Tool Compound
Alternate names: Src/Abl1 Kinase Inhibitor AZD424
Tool type: Small molecules
Tool sub-type: Inhibitor
Description: Potent and selective inhibitor of Src/Abl1 kinases showing additional activity against other Src family kinase members including Yes, Fgr, Lck, Hck, Fyn and Blk.
Suggested application in Alzheimer's disease, schizophrenia and treatment of alcoholism; Saracatinib, a related Src inhibitor has been used in clinical trials for Alzheimer's disease and alcoholism.
Research area: Cancer ; Cell Signaling & Signal Transduction ; Other
- For Research Use Only
- • Woodcock et al. 2018. Br J Cancer. 118(6):770-776. PMID: 29438361.
- • A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424.