RAP as an LRP1 antagonist
- Name Dudley K. Strickland
- Institute University of Maryland
Tool name: RAP as an LRP1 antagonist
Alternate names: receptor-associated protein
Tool type: Small molecules
Description: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1.
Research area: Cell Signaling & Signal Transduction ; Other
- For Research Use Only
- • Prasad et al. 2015. J Biol Chem. 290(28):17262-8. PMID: 26013822.
- • Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.