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Contributor Information

  • Name Dudley K. Strickland
  • Institute University of Maryland

Tool Details

  • Tool name: RAP as an LRP1 antagonist
  • Alternate names: receptor-associated protein
  • Tool type: Small molecules
  • Description: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1.
  • Research area: Cell Signaling & Signal Transduction ; Other

  • For Research Use Only

Target Details

  • Target: lipoprotein receptor-related protein 1

Application Details

Handling

  • Purity:
  • Solubility:
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Prasad et al. 2015. J Biol Chem. 290(28):17262-8. PMID: 26013822.
  •   Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.