SMALL MOLECULES
Contributor Information
- Name Dudley K. Strickland
- Institute University of Maryland
Tool Details
- Tool name: RAP as an LRP1 antagonist
- Alternate names: receptor-associated protein
- Tool type: Small molecules
- Application: inhibition of LRP1 function
- Description: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1.
- Research area: Cell Signaling & Signal Transduction; Other
- Additional notes: This RAP molecule was engineered to resist pH and heat-induced denaturation via the addition of a disulfide bond within the D3 domain and elimination of key histidine residues. This stable RAP molecule does not disassociate from LRP1 under acidic conditions and thus functions as a potent LRP1 antagonist both in-vitro and in-vivo.
- For Research Use Only
Target Details
- Primary target: lipoprotein receptor-related protein 1
Application Details
- Application: inhibition of LRP1 function
Handling
- Purity:
- Shipping conditions: Dry Ice
Documentation
- Available on request
Related Tools
References
- • Prasad et al. 2015. J Biol Chem. 290(28):17262-8. PMID: 26013822.
- • Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.
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