SMALL MOLECULES
Contributor Information
- Name Marta P. Pereira Morais
- Institute University of Bath
Tool Details
- Tool name: Glycated HSA Rhodamine Boronic Acid small molecule (tool compound)
- Alternate names: AGEs
- Tool type: Small molecules
- Description: Protein glycation, also known as non-enzymatic glycosylation, has been implicated in various disease states and is therefore an important biomarker for ageing and age-related chronic diseases such as diabetes, cardiovascular diseases, autoimmune diseases, cancer, and Alzheimer's disease. However their analysis is challenging due to the complexity of the protein-carbohydrate adducts. Fluorescent boronic acids like these enable the detection and identification of individual glycated proteins in complex samples through gel electrophoresis.
- Research area: Cancer; Cell Type or Organelle Marker; Fluorescent Cell Imaging
- Additional notes: This small molecule has been used to identify glycated proteins in human serum, insect hemolymph, and mouse brain homogenates.
- For Research Use Only
Target Details
- Primary target: Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein.
Application Details
Handling
- Purity:
- Shipping conditions: Dry Ice
Documentation
- Available on request
Related Tools
References
- • Pereira Morais et al. 2013. Sci Rep. 3:1437. PMID: 23531746.
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