SMALL MOLECULES
Contributor Information
- Institute Leiden University and Leiden University Medical Center
Tool Details
- Tool name: Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)
- Molecular formula: C31H29F4N6O4S [M+H]+
- Tool type: Small molecules
- Tool sub-type: Fluorescent Probe
- Molecular weight of the target: 657
- Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
- Description: Photoreactive probe to study the type 2 cannabinoid receptor (CB2R). LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorproated alkyne serves as ligation handle for the introduction of reporter groups.
- Research area: Drug Discovery & Development; Fluorescent Cell Imaging;
- Additional notes: Using proteomics, LEI-121 has shown to identify multidrug resistance protein 1, protein disulfide-isomerase, glutathione S-transferase Mu 6, 26S proteasome non-ATPase regulatory subunit 3 O and mitochondrial carnitine.acylcarnitine carrier protein.
- For Research Use Only
Target Details
- Target molecular weight: 657
Application Details
- Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
Handling
Documentation
Related Tools
References
- • Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.
- • Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.
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