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Contributor Information

  • Name Masaki Mori ; Hideshi Ishii ; Masamitsu Konno ; Hidetoshi Eguchi ; Naotsgu Haraguchi ; Reishi Toshiyama ; Nobuhiro Nishiyama ; Hiroyasu Takemoto - Osaka University ; Tokyo Institute of Technology ; Tokyo Institute of Technology
  • Institute Osaka University ; Tokyo Institute of Technology

Tool Details

  • Tool name: Poly(ethylene glycol)poly(lysine) block copolymerubenimex conjugate small molecule (tool compound)
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Description: The molecule exerts stronger inhibitory effect at lower concentrations that Ube alone,suggesting that PLys conjugation effectively increases the antitumor effect in HCC cells, presumably by targeting APN/CD13+cells, and enhances the strength of molecule-to-cell interactions.
  • Research area: Drug Discovery & Development

  • For Research Use Only

Target Details

  • Primary target: This conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells

Application Details

Handling

  • Purity:
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Toshiyama et al. 2019. Oncogene. 38(2):244-260. PMID: 30089817.