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Contributor Information

  • Name Jason Gestwicki
  • Institute University of Michigan

Tool Details

  • Tool name: Heat shock protein 70 (HSP70) inhibitor JG-231
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: The benzothiazole rhodacyanines, MKT-077 analogue, JG-231 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines and xenograft model. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
  • Research area: Cancer

  • For Research Use Only

Target Details

  • Target: Heat shock protein 70 (HSP70)

Application Details

Handling

  • Purity:
  • Solubility:
  • Storage conditions:
  • Shipping conditions: Dry Ice

Documentation

  • Available on request

References

  •   Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.
  •   Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.
  •   Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.
  •   Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.
  •   Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.
  •   Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.
  •   Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.