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Contributor Information

  • Name Jan Konvalinka ; Jirí Schimer ; Tomas Knedlik ; Jan Tykvart ; Frantisek Sedlak ; Pavel Majer ; Vaclav Navratil ; Petr Cigler ; Vladimir Subr ; Karel Ulbich ; Jiri Stroham ; Pavel Sacha
  • Institute Institute of Organic Chemistry and Biochemistry ; Institute of Macromolecular Chemistry ; Charles University

Tool Details

  • Tool name: anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)
  • Alternate names: Carbonic Anyhdrase IX; CA9; CA-IX
  • Tool type: Small molecules
  • Tool sub-type: Marker
  • Purpose: Marker
  • Description: An enzyme that in humans is encoded by the CA9 gene. - iBodiesŽ are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodiesŽ consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores). - These iBodiesŽ have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
  • Research area: Cell Signaling & Signal Transduction; Other
  • Additional notes: HPMA conjugate characteristics: MW: 111 000g/mol #Biotins/molecule: 33 Fluorochrome name: ATTO488 #Fluorochrome/molecule: 6 iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

  • For Research Use Only

Target Details

  • Primary target: Targeting human Carbonic Anhydrase (CAIX) using CAIX specific inhibitor

Application Details

Handling

  • Purity:
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Ĺ imon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
  • •  DvořákovĂĄ et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
  • •  Ĺ ĂĄcha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.