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anti-glutamate carboxypeptidase (GCPII) iBody small molecule (tool compound)

Cat. #157994

Name Jan Konvalinka ; Jirí Schimer ; Tomas Knedlik ; Jan Tykvart ; Frantisek Sedlak ; Pavel Majer ; Vaclav Navratil ; Petr Cigler ; Vladimir Subr ; Karel Ulbich ; Jiri Stroham ; Pavel Sacha
Institute Institute of Organic Chemistry and Biochemistry ; Institute of Macromolecular Chemistry ; Charles University

Tool name: anti-glutamate carboxypeptidase (GCPII) iBody small molecule (tool compound)
Alternate names: Glutamate Carboxypeptidase II, N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, prostate-specific membrane antigen (PSMA)
Tool type: Small molecules
Tool sub-type: Marker
Purpose: Marker
Description: An enzyme that in humans is encoded by FOLH1 (folate hydrolase 1). - iBodiesŽ are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodiesŽ consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores). - These iBodiesŽ have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Research area: Cell Signaling & Signal Transduction; Other
Additional notes: HPMA conjugate characteristics: MW: 148 800g/mol #Biotins/molecule: 38 Fluorochrome name: ATTO488 #Fluorochrome/molecule: 7 iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

Primary target: Targeting human Glutamate Carboxypeptidase II (GPCII) using GPCII specific inhibitor

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