SMALL MOLECULES
Contributor Information
- Name Pavel Sacha ; Jan Konvalinka ; Jirí Schimer ; Tomas Knedlik ; Jan Tykvart ; Frantisek Sedlak ; Pavel Majer ; Vaclav Navratil ; Petr Cigler ; Vladimir Subr ; Karel Ulbich ; Jiri Stroham
- Institute Charles University ; Institute of Organic Chemistry and Biochemistry ; Institute of Macromolecular Chemistry
Tool Details
- Tool name: Anti-fibroblast activation protein (FAP) iBody small molecule (tool compound)
- Alternate names: iBodyFAP
- Tool type: Small molecules
- Tool sub-type: Marker
- Purpose: Marker
- Description: Targeting human Fibroblast Activation Protein (FAP) using FAP specific inhibitor. - iBodiesŽ are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodiesŽ consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores). - These iBodiesŽ have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
- Research area: Epigenetics & Nuclear Signalling
- For Research Use Only
Target Details
- Primary target: NA
Application Details
Handling
- Shipping conditions: Dry Ice
Documentation
- Available on request
Related Tools
References
- • Ĺ imon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
- • DvoĹĂĄkovĂĄ et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
- • Ĺ ĂĄcha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.
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