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Contributor Information

  • Name Osvaldo Cox (Retired), Beatriz Zayas
  • Institute Universidad Ana G. Mendez

Tool Details

  • Tool name: NBQ-48 small molecule
  • Molecular formula: C22H26CIN3O2
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Molecular weight of the target: 389.8348
  • Application: cell hypoxia marker; fluorescence-based multiplex ELISA
  • Description: Inhibitor of growth in several cancer cell line models. This small molecule can also be used as a cell hypoxia marker in 2D and 3D colon cancer cell models.
  • Research area: Cancer; Fluorescent Cell Imaging
  • IUPAC: 7-benzyl-3- nitrobenzimidazo[3,2-a]quinolinium chloride
  • IC50: 100 uM (COLO205 cells under hypoxic conditions); 128 uM +/- 3 uM (U937 cells)

  • For Research Use Only

Target Details

  • Target molecular weight: 389.8348

Application Details

  • Application: cell hypoxia marker; fluorescence-based multiplex ELISA

Handling

  • Purity: 389.8348 g/mol
  • Solubility: 3 mM in water, 10ľM DMSO; 100 ľg/mL in DMSO
  • Storage conditions: 2-5°C in solution
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  VĂŠlez et al. 2017. Open Med Chem J. 11:54-65. PMID: 28761559.
  • •  Otero et al. 2015. J Cancer Res Ther Oncol. 1:. PMID: 26086027.
  • •  Vivas-MejĂ­a et al. 1998. Mol Cell Biochem. 178(1-2):203-12. PMID: 9546601.