Product Image

Contributor Information

  • Name Alessio Ciulli ; Michael Zengerle ; Kwok-Ho Chan
  • Institute University of Dundee

Tool Details

  • Tool name: MZ1 small molecule (tool compound)
  • Alternate names: BRD4, CAP, bromodomain containing 4, chromosome-associated protein, HUNK1, HUNKI, MCAP
  • Molecular formula: C49H60ClN9O8S2
  • Tool type: Small molecules
  • Molecular weight of the target: 1002.64
  • Description: (+)-JQ1 based PROTAC that selectively degrades BRD4 in cells
  • Research area: Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target molecular weight: 1002.64
  • Primary target: BRD4

Application Details

Handling

  • Purity: 1002.64 g/mol
  • Solubility: DMSO; Ethanol
  • Shipping conditions: Dry Ice

Documentation

References

  •   Zengerle et al. 2015. ACS Chem Biol. 10(8):1770-7. PMID: 26035625.