Tin Tungstate Nanoparticles Beta-SnWO4 small molecule (tool compound)
- Name Claus Feldmann
- Institute Karlsruhe Institute of Technology
Tool name: Tin Tungstate Nanoparticles Beta-SnWO4 small molecule (tool compound)
Tool type: Small molecules
Tool sub-type: Nanoparticle
Cancer type: Skin cancer; Digestive / Gastrointestinal cancer; Breast cancer
Application: Used to treat tumours in BALB/C mice orthotopically inoculated with the 4T1 breast cancer cell line. Reduced lymph node metastases.Killed 4T1 cells in vitro.
Description: Tin Tungstate nanoparticles act as photosensitizers for photodynamic tumor therapy of near-surface tumors via reiterated 5 min blue-light LED illumination.
Research area: Cancer; Metabolism
Additional notes: "The nanoparticulate inorganic photosensitizer Î˛-SnWO4 is suggested for photodynamic therapy (PDT) of near-surface tumors via reiterated 5 min blue-light LED illumination. Î˛-SnWO4 nanoparticles are obtained via water-based synthesis and comprise excellent colloidal stability under physiological conditions and high biocompatibility at low material complexity. Antitumor and antimetastatic effects were investigated with a spontaneously metastasizing (4T1 cells) orthotopic breast cancer BALB/c mouse model. Besides protamine-functionalized Î˛-SnWO4 (23 mg/kg of body weight, in PBS buffer), chemotherapeutic doxorubicin was used as positive control (2.5 mg/kg of body weight, in PBS buffer) and physiological saline (DPBS) as a negative control. After 21 days, treatment with Î˛-SnWO4 resulted in a clearly inhibited growth of the primary tumor (all tumor volumes below 3 cm3) as compared to the doxorubicin and DPBS control groups (volumes up to 6 cm3). Histological evaluations of lymph nodes and lungs as well as the volume of ipsilateral lymph nodes show a remarkable antimetastatic effect being similar to chemotherapeutic
doxorubicin butîaccording to blood countsîat significantly reduced side effects. On the basis of low material complexity,
high cytotoxicity under blue-light LED illumination at low dark and long-term toxicity, Î˛-SnWO4 can be an interesting
addition to PDT and the treatment of near-surface tumors, including skin cancer, esophageal/gastric/colon tumors as well
as certain types of breast cancer."
From Seidl et al 2016, ACS Nano, 10, 3149â3157.
- For Research Use Only
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