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Contributor Information

  • Name Claus Feldmann
  • Institute Karlsruhe Institute of Technology

Tool Details

  • Tool name: Tin Tungstate Nanoparticles Beta-SnWO4 small molecule (tool compound)
  • Tool type: Small molecules
  • Tool sub-type: Nanoparticle
  • Cancer type: Skin cancer; Digestive / Gastrointestinal cancer; Breast cancer
  • Application: Used to treat tumours in BALB/C mice orthotopically inoculated with the 4T1 breast cancer cell line. Reduced lymph node metastases.Killed 4T1 cells in vitro.
  • Description: Tin Tungstate nanoparticles act as photosensitizers for photodynamic tumor therapy of near-surface tumors via reiterated 5 min blue-light LED illumination.
  • Research area: Cancer; Metabolism
  • Additional notes: "The nanoparticulate inorganic photosensitizer β-SnWO4 is suggested for photodynamic therapy (PDT) of near-surface tumors via reiterated 5 min blue-light LED illumination. β-SnWO4 nanoparticles are obtained via water-based synthesis and comprise excellent colloidal stability under physiological conditions and high biocompatibility at low material complexity. Antitumor and antimetastatic effects were investigated with a spontaneously metastasizing (4T1 cells) orthotopic breast cancer BALB/c mouse model. Besides protamine-functionalized β-SnWO4 (23 mg/kg of body weight, in PBS buffer), chemotherapeutic doxorubicin was used as positive control (2.5 mg/kg of body weight, in PBS buffer) and physiological saline (DPBS) as a negative control. After 21 days, treatment with β-SnWO4 resulted in a clearly inhibited growth of the primary tumor (all tumor volumes below 3 cm3) as compared to the doxorubicin and DPBS control groups (volumes up to 6 cm3). Histological evaluations of lymph nodes and lungs as well as the volume of ipsilateral lymph nodes show a remarkable antimetastatic effect being similar to chemotherapeutic doxorubicin butaccording to blood countsat significantly reduced side effects. On the basis of low material complexity, high cytotoxicity under blue-light LED illumination at low dark and long-term toxicity, β-SnWO4 can be an interesting addition to PDT and the treatment of near-surface tumors, including skin cancer, esophageal/gastric/colon tumors as well as certain types of breast cancer." From Seidl et al 2016, ACS Nano, 10, 3149−3157.

  • For Research Use Only

Target Details

  • Primary target: Near-surface tumours

Application Details

  • Application: Used to treat tumours in BALB/C mice orthotopically inoculated with the 4T1 breast cancer cell line. Reduced lymph node metastases.Killed 4T1 cells in vitro.

Handling

  • Purity:
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Seidl et al. 2016. ACS Nano. 10(3):3149-57. PMID: 26894966.
  • •  Ungelenk et al. 2014. Chem Commun (Camb). 50(50):6600-3. PMID: 24824575.
  • •  Ungelenk et al. 2012. Chem Commun (Camb). 48(63):7838-40. PMID: 22735092.