Product Image

Contributor Information

  • Name Cristian Salas
  • Institute Pontificia Universidad Catolica de Chile

Tool Details

  • Tool name: CS-5c Bcr-Abl and Btk small molecule kinase inhibitors
  • Molecular formula: C26H29FN8
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Cancer type: Blood cancer
  • Molecular weight of the target: 472.5605
  • Description: This compound inhibits in nanomolar scale for Bcr-Abl (40 nM) and sub-micromolar scale for Btk kinases (0,58 M), both are related to the genesis and progression of myeloid and lymphoid leukaemia, respectively
  • Research area: Cancer; Drug Discovery & Development; Other
  • IUPAC: 9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2,6-diamine

  • For Research Use Only

Target Details

  • Target molecular weight: 472.5605
  • Primary target: Bcr-Abl and Btk kinases

Application Details

Handling

  • Purity: 472.5605 g/mol
  • Solubility: DMSO
  • Storage conditions: Away from UV light
  • Shipping conditions: Dry Ice

Documentation

References

  •   Bertrand et al. 2020. Bioorg Chem. 94:103361. PMID: 31699386.