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Contributor Information

  • Name Laura Machesky
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: BDP-13176 Fascin-1 Inhibitor
  • Alternate names: FSCN1, Fascin1, Fascin, Fascin actin binding protein
  • Chemical name: 5-(3,4-dichlorobenzyl)-4-oxo-1-(piperidin-4-yl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridine-7-carboxamide
  • Tool type: Small molecules
  • Tool sub-type: Inhibitor
  • Purpose: Inhibitor
  • Description: Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in cancer cell metastasis by promoting cell migration and invasion. BDP-13176 is a has potent affinity to Fascin-1, and is capable of inhibiting the binding of Fascin-1 to filamentous actin.
  • Research area: Cancer

  • For Research Use Only

Target Details

  • Target: Fascin-1

Application Details


  • Purity: 497 g/mol
  • Shipping conditions: Dry Ice


  • Available on request


  •   Francis et al. 2019. Bioorg Med Chem Lett. 29(8):1023-1029. PMID: 30773430.