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Contributor Information

  • Name Anthony Dear
  • Institute Monash University
  • Primary citation Sama GR et al. Bioorg Med Chem Lett. 2020. 30(16):127291. PMID: 32631513

Tool Details

  • Tool name: Photo-activated Histone Deacetylase Inhibitor
  • Alternate names: Photo-MCT-3, Caged MCT-3. Photo-metacept-3, Caged metacept-3
  • Molecular formula: C27H29N3O10S
  • Chemical name: 4-(2-methoxy-4-(1-((3'-(methylsulfonamido)-[1,1'-biphenyl]-4-carboxamido)oxy)ethyl)-5-nitrophenoxy)butanoic acid
  • Tool type: Small Molecule
  • Tool sub-type: Inhibitor
  • Molecular weight of the target: MW 587.3 Da
  • Description: Photo-activatable HDAC inhibitors offer a useful tool for targeted control of antiproliferative activity and other molecular effects in a wide range of biological systems
  • Is the structure published?: Yes
  • Additional notes: Ultraviolet (UV) 365nm light source required for cleavage to active compound MCT-3. Parent compound MCT-3 has been used extensively as a HDACi by the originating group. Please search Pubmed for relevant publications.

  • For Research Use Only

Target Details

  • Target molecular weight: MW 587.3 Da
  • Primary target: Histone Deacetylase (HDAC)

Application Details


  • Format: Dry
  • Purity: >95% HPLC
  • Solubility: DMSO
  • Storage conditions: Store powder@RT, Dissolved -20oC
  • Shipping conditions: RT



  •   Liu H et al. Cardiovasc Eng Technol. 2021. 12(4):466-473. PMID: 33709249