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Contributor Information

  • Name Cornelis Vlaar
  • Institute University of Puerto Rico
  • Primary citation Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027

Tool Details

  • Tool name: Carbazole derivative HV-118
  • Tool type: small molecule
  • Purpose: Designed to mimic the 'U-shaped' conformation adopted by EHop-016 as it binds Rac1
  • Cancer type: Breast cancer
  • Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
  • Description: Carbazole derivative HV-118 is a highly potent novel anti-cancer and anti-metastatic carbazole derivative. Carbozole derivatives based on EHop-016 generated to mimic the ‘U-shaped’ conformation adopted by EHop-016 as it binds Rac2
  • Research area: Cancer
  • IC50: 100 nM

  • For Research Use Only

Target Details

  • Primary target: Rac
  • Secondary targets: Rac 1

Application Details

  • Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42

Handling

Documentation

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References

  • •  Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027