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Contributor Information

  • Name Suranganie Dharmawardhane
  • Institute University of Puerto Rico
  • Primary citation Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527

Tool Details

  • Tool name: EHop-016 Rac1 Inhibitor
  • Tool type: small molecule
  • Purpose: Designed to be a more potent Rac Inhibitor with possible clinical applications
  • Cancer type: Breast cancer
  • Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells
  • Description: EHop-016 Rac1 Inhibitor is a novel small molecule directed at metastatic breast cancer. Potent Rac inhibitor reporting the identification and characterization of the biological activity of EHop-016, a novel NSC23766 derivative that inhibits Rac1 100-fold more effectively than the parent compound.
  • Research area: Cancer
  • IC50: 1.1mu.M

  • For Research Use Only

Target Details

  • Primary target: Rac
  • Secondary targets: Rac 1 and Rac 3

Application Details

  • Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells

Handling

Documentation

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References

  • •  Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527