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Contributor Information

  • Name Dr Fiona Benson
  • Institute Lancaster University

Tool Details

  • Tool name: pKH2 Beta-Synuclein P123H Vector
  • Tool type: Vector
  • Description: pKH2 ("P123H") is a derivative of pET15b with the open reading frame encoding the P123H mutant human beta-synuclein (β-synuclein) cloned in via the vector NdeI and BamHI restriction sites. It was constructed via site-specific mutagenesis of pJEK12 (pET15b-wt β-synuclein), replacing the C at position 368 in the ORF nucleotide sequence with A, thus altering the 123rd codon from CCC encoding proline (P) to CAC encoding histidine (H). In this construct P123H β-synuclein is expressed as a fusion protein with an N-terminal six His tag.
  • Research area: Neurobiology

  • For Research Use Only

Target Details

  • Target: Beta-synuclein

Application Details



  • Available on request