- Name Danny Huang
- Institute Cancer Research UK, Glasgow: The Beatson Institute
Tool name: pRSF-1b-UbcH5B Vector
Alternate names: UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
Tool type: Vector
Tool sub-type: pRSF-1b
Description: Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases.
UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms.
Research area: Cancer; Cell Signaling & Signal Transduction; Epigenetics & Nuclear Signalling
Bacterial resistance: Kanamycin
- For Research Use Only
- • Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.
- • BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.