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Contributor Information

  • Name Danny Huang
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: pRSF-1b-UbcH5B Vector
  • Alternate names: UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
  • Tool type: Vector
  • Tool sub-type: pRSF-1b
  • Description: Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms.
  • Research area: Cancer; Cell Signaling & Signal Transduction; Epigenetics & Nuclear Signalling
  • Bacterial resistance: Kanamycin

  • For Research Use Only

Target Details

  • Target: UbcH5B

Application Details

Handling

  • Storage conditions: -20°C
  • Shipping conditions: Dry Ice

Documentation

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  • Available on request

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References

  • •  Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.
  • •  BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.