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Contributor Information

  • Name Constanze Bonifer
  • Institute University of Birmingham

Tool Details

  • Tool name: pSIEW-RUNX1-EVI1 Vector
  • Alternate names: Runt Related Transcription Factor 1, RUXN1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, acute myeloid leukemia 1 protein, core-binding factor subunit alpha-2
  • Tool type: Vector
  • Tool sub-type: pSIEW
  • Description: Runt-related transcription factor 1, a protein that in humans is encoded by the RUNX1 gene, that regulates the differentiation of hematopoietic stem cells into mature blood cells and plays a major role in the development of the neurons that transmit pain. It belongs to the RUNX family of genes also known as core binding factor-a, and RUNX proteins form heterodimeric complexes with these confering increased DNA binding and stability. Chromosomal translocations involving RUNX1 are associated with several types of leukemia including M2 Acute myeloid leukaemia and DNA mutations are implicated in cases of breast cancer.
  • Research area: Cancer; Cell signaling and signal transduction; Genetics
  • Bacterial resistance: Ampicillin

  • For Research Use Only

Target Details

  • Target: RUNX1-EVI1 (chimeric gene)

Application Details

Handling

  • Storage conditions: -20°C
  • Shipping conditions: Dry Ice

Documentation

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References

  • •  Maki et al. 2008. Cancer Sci. 99(10):1878-83. PMID: 19016745.
  • •  Role of the RUNX1-EVI1 fusion gene in leukemogenesis.